Beneath the Copper—Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review

Richard A. Rosencrantz; Lesli LeCompte; Yasmin Yusuf

doi:10.1055/s-0035-1567828

Seminars in Liver Disease, Table of Contents

Semin Liver Dis 2015; 35(04): 434-438
DOI: 10.1055/s-0035-1567828

Diagnostic Problems in Hepatology

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Beneath the Copper—Pediatric Wilson's Disease Cirrhosis and Hepatocellular Carcinoma: A Case Report with Literature Review

Authors

Richard A. Rosencrantz

¹Department of Pediatrics, Section of Gastroenterology and Hepatobiliary Diseases, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York

²Center for Transplantation, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
Lesli LeCompte

³Department of Radiology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York
Yasmin Yusuf

⁴Department of Pathology, New York Medical College, Maria Fareri Children's Hospital at Westchester Medical Center, Valhalla, New York

Abstract

Primary hepatic malignancies are uncommon in pediatrics. Tumors such as hepatocellular carcinoma (HCC) develop typically in the setting of chronic liver disease. The incidence of HCC in Wilson's disease-related cirrhosis is disproportionately lower than in many other forms of end-stage liver disease. A preadolescent girl presented with Wilson's disease cirrhosis and a HCC requiring orthotopic liver transplantation. This case highlights the need to consider hepatic malignancies even in young Wilson's disease patients. Pediatric Wilson's disease and the hepatic tumor literature are reviewed.

Keywords

Wilson's disease - hepatocellular carcinoma - pediatrics - liver transplantation

Full Text

References

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